Data underpinning "Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments"

The data in this archive was acquired to investigate the coupling between cerebral blood flow and cerebral blood volume across different vascular compartments. These results will form the basis of a forthcoming publication. Please reference this dataset (version v1.1.0) if you use it in your work. Wesolowski R, Blockley NP, Driver ID, Francis ST, Gowland PA. Data underpinning "Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments". Zenodo 2018. doi: 10.5281/zenodo.1411018. 

This dataset contains measurements of the haemodynamic responses of different compartments to a visual stimulus (8Hz red LED goggles, 19.2s ON, 40.8s OFF). Time course data are cycle averaged for the following haemodynamic properties;

  1. Arterial cerebral blood volume (CBVa) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBVa.
  2. Cerebral blood flow (CBF) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBF.
  3. Total cerebral blood volume (CBVtot) measured using bolus injections of a Gadolinium based contrast agent combined with T2* weighed gradient echo EPI.

In addition, weighted mean and standard deviation of the changes in these parameters are presented using time windows of 9.6–19.2s and 40.8–60s for ON and OFF, respectively. Weighting is performed with respect to the number of voxels present in each of the subjects regions of interest.

Time course data were extracted from two different regions of interest;

  1. ROICBF: defined using a CBF localiser
  2. ROICOMMON: defined using the overlap of CBF, CBVa and CBVtot localisers

Furthermore, the transit times for CBF and CBVa were estimated for an average stimulus cycle and mean values extracted using time windows of 9.6–19.2s and 40.8–60s for ON and OFF, respectively. These data were extracted from ROICBF.

Changes

- Addition of propagation of uncertainty for CBVv and the Grubb constants alpha_tot and alpha_a.