Targeting glycolysis to prevent atherosclerotic plaque formation in mice

Atherosclerosis is an inflammatory disorder characterized by accumulation of lipid- rich plaques in the arterial wall. Clinical evidence has recently shown that intraplaque (IP) angiogenesis promotes unstable vascular disease and thus contributes to increased risk of myocardial infarction, stroke and peripheral arterial disease. Because endothelial cells (ECs) rely on glycolysis for up to 85% of their energy demand, we investigated whether glycolysis inhibition may represent a novel strategy to prevent IP neovascularization and plaque formation.