Sensitive detection of mitochondrial structural alterations on simulated data

2018-06-27T00:00:00Z (GMT) by Swaraj Basu Erik Larsson

Testing three different sensitive sequence aligners (BLAT, BLASTn, LAST) on simulated data generated from reference human mitochondrial genome along with genomes with a deletion and a duplication.  The aim is to identify the aligner best suited for detection of large structural alterations in the mitochondrial genome.